Effect of tartrazine on blood urea nitrogen, creatinine levels, and renal tubular necrosis in adult male Wistar rats (Rattus norvegicus): an experimental study

Introduction: Tartrazine is still one of the most widely used coloring agents in pharmaceutical, cosmetic, and food industries; various hazardous consequences have been identified rodents humans, including impaired kidney function. This current study aimed to evaluate effect tartrazine on biochemical parameters structures kidney. Methods: Twenty-four adult male Wistar rats were divided into four groups 6 each. The experimental animals received orally at a dose 3.75, 7.5, 15 mg/kg body weight along with normal diet. control group only drinking water. was carried out for 21 days. At end experiment, (blood urea nitrogen serum creatinine) histopathological examinations performed animal tissues. Results: Our findings revealed significant increase creatinine levels tartrazine-treated compared controls (p < 0.05). section treated showed lumen compression tubular cells loss integrity renal tubule membrane. associated increases percentage necrosis dose-dependent manner Conclusions: concluded that oral administration affected by increasing nitrogen, levels, rats. results intake could cause adverse health effects.